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Barbiturates can induce hepatic microsomal enzymes causing elevated metabolism and lowered anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); individuals stabilized on anticoagulant therapy may well involve dosage adjustments if barbiturates are additional to or withdrawn from their dosage routine

pentobarbital will lower the extent or outcome of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will reduce the level or impact of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will lessen the extent or effect of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will reduce the extent or outcome of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

pentobarbital will lessen the level or outcome of doxorubicin liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will minimize the level or result of cevimeline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.

pentobarbital will lower the level or influence of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Keep away from coadministration click here of lefamulin with powerful or average CYP3A inducers Except if the benefit outweighs threats. Check for reduced efficacy.

pentobarbital will decrease the level or outcome of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.

Reserve concomitant prescribing of those medicines in patients for whom other cure alternatives are inadequate. Restrict dosages and durations to the minimum expected. Keep track of carefully for signs of respiratory melancholy and sedation.

Keep an eye on Carefully (1)pentobarbital will decrease the extent or result of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lower the level or impact of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. The efficacy of hormonal contraceptives could be lowered. Utilization of a nonhormonal contraceptive is suggested.

pentobarbital will reduce the extent or result of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will decrease the extent or result of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.